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π§ Neuroscience
Foundations
Neuroanatomy
Cellular & Molecular Neuroscience
Systems Neuroscience
Cognitive Neuroscience
Computational Neuroscience
Brain-Computer Interface
Neurotech Frontiers
Neuro Disorders
Cellular & Molecular Neuroscience
Neuron β The Basic Unit of the Nervous System
Synapse β Chemical / Electrical Junctions Between Neurons
Action Potential β The Neuron's Digital Signal
Hodgkin-Huxley Equations β Biophysical Neuron Model
Neurotransmitters β Glutamate, GABA, DA, 5-HT, ACh, etc.
LTP / LTD β Long-Term Synaptic Plasticity, Cellular Basis of Learning & Memory
Ion Channels β The Brain's "Transistors"
Glia β Beyond "Support Cells"
Dendrites
Membrane Potential β Foundation of Neuronal Electrical Signals
Neurotransmitter Receptors
Second Messengers & Signal Transduction
Synaptic Vesicle Cycle
Myelination
Neurotrophins
Axonal Transport
Neuron Types & Cell Taxonomy
Gap Junctions & Electrical Synapses
Astrocyte Function
Activity-Dependent Gene Expression
Table of Contents
1. Experimental Protocol
1.1 LTP Induction
1.2 LTD Induction
2. Molecular Mechanism (NMDA-dependent LTP)
2.1 NMDA as Coincidence Detector
2.2 LTD: Low CaΒ²βΊ β Calcineurin β AMPA Endocytosis
3. STDP (Spike-Timing-Dependent Plasticity)
4. Early vs Late LTP
4.1 E-LTP (1-3 hours)
4.2 L-LTP (> 3 hours, "synaptic consolidation")
5. LTP Types
5.1 NMDA-dependent (Schaffer collateral β CA1)
5.2 Non-NMDA (mossy fiber β CA3)
5.3 Cerebellar LTD
6. Behavioral Correlates
6.1 Hippocampal LTP β Spatial Memory
6.2 Amygdala LTP β Fear Conditioning
6.3 Cortex LTP β Perceptual Learning
7. PyTorch β STDP Learning Rule
8. Relation to Backprop
8.1 Backprop
8.2 STDP
8.3 Modern Attempts
9. Pathology
10. History
11. Common Pitfalls
11.1 LTP β Memory
11.2 NMDA Not Unique
11.3 Saturation
11.4 In vitro β In vivo
11.5 Network Plasticity
12. Related Concepts
References